Throughout the trial, Glaxo maintained that it did not market Paxil to women of childbearing years or pregnant women. In fact, in her opening statement, Varner told the jury: "You will hear from that chair the folks who made the marketing decisions at GSK."
"They will tell you that GSK did not, repeat, did not target pregnant women, did not target women of childbearing age," she said.
Yet, in a 2003 supplement titled, "Special Issues Related to the Treatment of Depression in Women," for the Journal of Clinical Psychiatry, Yonkers published an article derived from the teleconference, "Treating Depression: New Choices for a Chronic Problem," supported by an unrestricted educational grant from Glaxo, which promoted the use of SSRIs by women from youth to old age.
In the conclusion section, Yonkers wrote, "SRIs (SSRIs) appear to be an efficacious treatment for women suffering from various depressive disorders throughout the life cycle. These agents have expanded treatment options for many women, especially women who experience intermittent symptoms such as with PMDD, and side effects of SRIs are typically less severe than those of TCAs."
"SRIs appear to improve depressive symptoms in pregnant women and women suffering from postpartum depression, and they are a relatively safe option for breastfeeding mothers," she said. "Additionally, their effectiveness appears to be enhanced by estrogen, making them a favorable treatment option for older women suffering from postmenopausal depression."
In 2004, Yonkers, Cohen, and authors that included two Glaxo employees, published a paper in, "Psychosomatic Medicine," on a study titled, "Paroxetine Controlled Release for Premenstrual Dysphoric Disorder: A Double-Blind, Placebo Controlled Trial."
In the November 1, 2006 issue of "Journal of Women's Health," Yonkers, Cohen and others, published a paper titled, "Expert Guidelines for the Treatment of Severe PMS, PMDD, and Comorbidities: The Role of SSRIs."
This work was supported by an educational grant-in-aid from Glaxo, the disclosure advised. "Several treatment modalities are beneficial in PMDD and severe PMS, but the selective serotonin reuptake inhibitors (SSRIs) have emerged as first-line therapy," the abstract states.
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