It's actually being incorporated into the collagen. Collagen is the most common protein in the body. Twenty-five percent of the body's proteins are collagen molecules. Collagen contains a huge amount of glycine. Twenty-to 25% of the amino acids within collagen are glycines. It is really, really unusual in that respect.
So it has a huge opportunity to be destroyed by glyphosate and it depends upon those glycines to form its helical structure. It has this triple helix structure that it forms and it has a glycine at every third residue to make that structure work. If you replace those glycines with glyphosate randomly you're going to mess up the structure of the collagen. You're going to mess up its tensile strength, its flexibility. You're going to mess up its ability to hold water and you're going to cause things like rheumatoid arthritis and all kinds of bone pain, joint pain that we're seeing. You're going to cause things like an epidemic in opioid drug overdoses. I think it's directly connected to that.
The protein doesn't work properly, because it has this extra thing attached to the nitrogen which is this methylphosponyl group and that thing is negatively charged and bulky so it totally messes up. Glycine is the smallest amino acid. It has no side chain and it's chosen in certain places in proteins because of that. It has a central role that it plays in many proteins. This is what I'm finding. I'm still finding new proteins every day that have essential glycines that would cause the disease if those glycines are replaced and it's just astonishing that you can actually explain very easily all these diseases that are highly correlated with glyphosate usage.
We've had exponential growth of glyphosate usage on core crops in the United States over the past two decades in step with the exponential growth in autism and Alzheimer's disease and kidney failures, and all these different problems, including diabetes, are connected. I think they're directly linked to the glyphosate which is accumulating in our tissues.
Monsanto has a study that Monsanto researchers did in 1989 with something called a blue gill sunfish. They exposed this fish to radio-labelled glyphosate. They had carbon 14 put into the glyphosate so they could track it and then they looked at the tissues of the fish and they found
measurable levels of this radio-label in the tissues and when they tried to detect the glyphosate. They found that the method that they used to detect glyphosate depended upon it being an independent molecule and they found only 17% of the radio-label could be accounted for explicitly as glyphosate. What happened to the glyphosate?
Once they added a digestive enzyme that breaks proteins down into individual amino acids they increased the yield up to something like 57%, still missing quite a bit of the radio-label, which means they were able to break the protein down but not completely. So I think glyphosate makes the protein difficult to break down as well as messing up its ability to do its job, it makes it difficult to break it down. So you end up with a slow accumulation of glyphosate-contaminated proteins that your body can't clear.
Of course it also messes up the sulphate which is needed to break down cellular debris. So you've got these busted proteins that you can't get rid of because you don't have enough sulphate to create the acidic environment that you need to digest and to break down those broken proteins.
Questioner: I'm just going to go over that to make sure that I understand. So the lysosomes are cellular organelles. They're basically machines that you use in your cells to break down and recycle tissue. Recycle cellular components. So as you were talking about before, how the sulphate is so fundamentally important for that process and the fact that glyphosate not only disrupts this eNOS enzyme but there are several other ways in which it disrupts sulphate metabolism. So if there is an accumulation of glyphosate and then there is a subsequent or simultaneous decrease in the sulphate availability, it's not going to spell out very good things, is it?
Stephanie: No. In fact what will happen is, for example, you will
accumulate amyloid beta plaque and get Alzheimer's disease. I absolutely think there is a connection between the broken proteins and amyloid plaques. They have these things called motifs which are patterns that show up in certain proteins that are essential for their function and there's a motif that shows up in the Alzheimer's plaque which is called a GXXXG motif. The two g's stand for glycine and the x's stand for wildcards. So you have a glycine amino acid and then three other amino acids and then another glycine in that pattern, GXXXG motif. The amyloid beta plaque has three of these that are highly conserved. There are other molecules that also have this GXXXG motif that are trans-membrane proteins.
The Alzheimer's plaque comes from a trans-membrane protein that becomes disrupted and ends up as a soluble protein in the cytoplasm instead of its proper position in the membrane and it does this under strange conditions that they don't understand but they are targeting that GXXXG motif as being central to the problem because they can find that piece that has that in it, causes the plaque to form. So they'resuspecting that those glycines are somehow connected to Alzheimer's. But what they don't understand is that it's because they're not glycine, they're glyphosates that that's happening.
The glyphosate creates a negative charge. That causes it to bind to aluminum and the aluminum causes these molecules to hook together, the aluminum ties them together because you have the +3 aluminum charge and then the two negatively charged glyphosate molecules in two separate instances of this protein that then stick to the aluminum and stick together so you form this kind of complex of these molecules in the cytoplasm which is not where they're supposed to be and which is the source of trouble for the neuron that causes it to die.
Christopher Exley has been doing a lot of research on aluminum. He has recently found high levels of aluminum in autism brains which is quite exciting to me because I've written about aluminum and autism. I think it is a major player in the autism problem. I've written about the glyphosate making the aluminum much more toxic than it would otherwise because the glyphosate binds to the aluminum and neutralizes its positive charge, which makes it much easier for it to get across the gut barrier. And glyphosate also opens up the gut barrier; it opens up the brain barrier and allows aluminum to gain access to the brain and both
Alzheimer's and autism are going up dramatically in step with glyphosate usage and both of those have been found to have high levels of aluminum in the brain in association with them. Post-mortem when they examine the brain they find high levels of aluminum.
Elliot: Just back onto glyphosate, if we could, just go over some of the ways in which it does disrupt sulphate metabolism. You've explained how it inhibits eNOS or stops eNOS from working, but it also has lots of other ways in which it disrupts it, doesn't it?
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